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When environmental conditions permanently change, evolutionary discordance arises between a species’ genome and its environment, and stabilizing selection is replaced by directional selection, moving the average population genome to a new set point (1,2).

Initially, when permanent environmental changes occur in a population, individuals bearing the previous average status quo genome experience evolutionary discordance (2,3).

Personals are for people local to Anderson, SC and are for ages 18 of either sex.

From the Department of Health and Exercise Science, Colorado State University, Fort Collins (LC); the Departments of Radiology and Anthropology, Emory University, Atlanta (SBE); the Department of Medicine and UCSF/Moffitt General Clinical Research Center, University of California, San Francisco (AS); the Department of Food Science, RMIT University, Melbourne, Australia (NM); the Department of Medicine, Lund University, Sweden (SL); the Department of Food Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN (BAW); the Mid America Heart Institute, Cardiovascular Consultants, Kansas City, MO (JHO); and the Human Nutrition Unit, Department of Biochemistry, University of Sydney, Australia (JB-M)There is growing awareness that the profound changes in the environment (eg, in diet and other lifestyle conditions) that began with the introduction of agriculture and animal husbandry ≈10000 y ago occurred too recently on an evolutionary time scale for the human genome to adjust.

In the United States, chronic illnesses and health problems either wholly or partially attributable to diet represent by far the most serious threat to public health.

Sixty-five percent of adults aged ≥20 y in the United States are either overweight or obese (13), and the estimated number of deaths ascribable to obesity is 280184 per year (14).

Our free personal ads are full of single women and men in Anderson looking for serious relationships, a little online flirtation, or new friends to go out with.Instead of searching the newspaper or a disorganized classifieds site, you will find all the South Carolina classifieds with pictures and detailed descriptions in neat categories.We feature real estate listings, jobs, pets, auto listings (both used and new) rental listings, personal ads, service ads, tickets, and items for sale.There is growing awareness that the profound environmental changes (eg, in diet and other lifestyle conditions) that began with the introduction of agriculture and animal husbandry ≈10000 y ago occurred too recently on an evolutionary time scale for the human genome to adapt (2–5).In conjunction with this discordance between our ancient, genetically determined biology and the nutritional, cultural, and activity patterns in contemporary Western populations, many of the so-called diseases of civilization have emerged (2–12).Cancer is the second leading cause of death (25% of all deaths) in the United States, and an estimated one-third of all cancer deaths are due to nutritional factors, including obesity (18).In the 5–7 million-year period since the evolutionary emergence of hominins (bipedal primates within the taxonomic tribe hominini; note that the newer term ) ≥20 species may have existed (Figure 1) (19).Before the development of agriculture and animal husbandry hominin dietary choices would have been necessarily limited to minimally processed, wild plant and animal foods.With the initial domestication of plants and animals, the original nutrient characteristics of these formerly wild foods changed, subtly at first but more rapidly with advancing technology after the Industrial Revolution.However, there are universal characteristics of preagricultural hominin diets that are useful in understanding how the current Western diet may predispose modern populations to chronic disease.Increasingly, clinical trials and interventions that use dietary treatments with nutritional characteristics similar to those found in preindustrial and preagricultural diets have confirmed the beneficial health consequences predicted by the template of evolutionary discordance theory.


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